船上自治技术，如规划和调度，识别科学目标和基于内容的数据摘要，将导致令人兴奋的新空间科学任务。然而，尚未研究具有此类船上自治能力的经营任务的挑战，这是足以在使命概念中考虑的细节水平。这些自主功能需要更改当前的操作流程，实践和工具。我们制定了一个案例研究，以评估使运营商和科学家通过促进地面人员和车载算法之间的共同模型来运营自主航天器所需的变化。我们评估使运营商和科学家能够向航天器传达所需的新的操作工具和工作流程，并能够重建和解释船上和航天器状态的决定。这些工具的模型用于用户学习，了解过程和工具在实现共享理解框架方面的有效性，以及在运营商和科学家有效实现特派团科学目标的能力。

An increasing number of public datasets have shown a marked clinical impact on assessing anatomical structures. However, each of the datasets is small, partially labeled, and rarely investigates severe tumor subjects. Moreover, current models are limited to segmenting specific organs/tumors, which can not be extended to novel domains and classes. To tackle these limitations, we introduce embedding learned from Contrastive Language-Image Pre-training (CLIP) to segmentation models, dubbed the CLIP-Driven Universal Model. The Universal Model can better segment 25 organs and 6 types of tumors by exploiting the semantic relationship between abdominal structures. The model is developed from an assembly of 14 datasets with 3,410 CT scans and evaluated on 6,162 external CT scans from 3 datasets. We rank first on the public leaderboard of the Medical Segmentation Decathlon (MSD) and achieve the state-of-the-art results on Beyond The Cranial Vault (BTCV). Compared with dataset-specific models, the Universal Model is computationally more efficient (6x faster), generalizes better to CT scans from varying sites, and shows stronger transfer learning performance on novel tasks. The design of CLIP embedding enables the Universal Model to be easily extended to new classes without catastrophically forgetting the previously learned classes.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Background: Encouraged by the success of pretrained Transformer models in many natural language processing tasks, their use for International Classification of Diseases (ICD) coding tasks is now actively being explored. In this study, we investigate three types of Transformer-based models, aiming to address the extreme label set and long text classification challenges that are posed by automated ICD coding tasks. Methods: The Transformer-based model PLM-ICD achieved the current state-of-the-art (SOTA) performance on the ICD coding benchmark dataset MIMIC-III. It was chosen as our baseline model to be further optimised. XR-Transformer, the new SOTA model in the general extreme multi-label text classification domain, and XR-LAT, a novel adaptation of the XR-Transformer model, were also trained on the MIMIC-III dataset. XR-LAT is a recursively trained model chain on a predefined hierarchical code tree with label-wise attention, knowledge transferring and dynamic negative sampling mechanisms. Results: Our optimised PLM-ICD model, which was trained with longer total and chunk sequence lengths, significantly outperformed the current SOTA PLM-ICD model, and achieved the highest micro-F1 score of 60.8%. The XR-Transformer model, although SOTA in the general domain, did not perform well across all metrics. The best XR-LAT based model obtained results that were competitive with the current SOTA PLM-ICD model, including improving the macro-AUC by 2.1%. Conclusion: Our optimised PLM-ICD model is the new SOTA model for automated ICD coding on the MIMIC-III dataset, while our novel XR-LAT model performs competitively with the previous SOTA PLM-ICD model.

Deepfakes are computationally-created entities that falsely represent reality. They can take image, video, and audio modalities, and pose a threat to many areas of systems and societies, comprising a topic of interest to various aspects of cybersecurity and cybersafety. In 2020 a workshop consulting AI experts from academia, policing, government, the private sector, and state security agencies ranked deepfakes as the most serious AI threat. These experts noted that since fake material can propagate through many uncontrolled routes, changes in citizen behaviour may be the only effective defence. This study aims to assess human ability to identify image deepfakes of human faces (StyleGAN2:FFHQ) from nondeepfake images (FFHQ), and to assess the effectiveness of simple interventions intended to improve detection accuracy. Using an online survey, 280 participants were randomly allocated to one of four groups: a control group, and 3 assistance interventions. Each participant was shown a sequence of 20 images randomly selected from a pool of 50 deepfake and 50 real images of human faces. Participants were asked if each image was AI-generated or not, to report their confidence, and to describe the reasoning behind each response. Overall detection accuracy was only just above chance and none of the interventions significantly improved this. Participants' confidence in their answers was high and unrelated to accuracy. Assessing the results on a per-image basis reveals participants consistently found certain images harder to label correctly, but reported similarly high confidence regardless of the image. Thus, although participant accuracy was 62% overall, this accuracy across images ranged quite evenly between 85% and 30%, with an accuracy of below 50% for one in every five images. We interpret the findings as suggesting that there is a need for an urgent call to action to address this threat.

Objective: Thigh muscle group segmentation is important for assessment of muscle anatomy, metabolic disease and aging. Many efforts have been put into quantifying muscle tissues with magnetic resonance (MR) imaging including manual annotation of individual muscles. However, leveraging publicly available annotations in MR images to achieve muscle group segmentation on single slice computed tomography (CT) thigh images is challenging. Method: We propose an unsupervised domain adaptation pipeline with self-training to transfer labels from 3D MR to single CT slice. First, we transform the image appearance from MR to CT with CycleGAN and feed the synthesized CT images to a segmenter simultaneously. Single CT slices are divided into hard and easy cohorts based on the entropy of pseudo labels inferenced by the segmenter. After refining easy cohort pseudo labels based on anatomical assumption, self-training with easy and hard splits is applied to fine tune the segmenter. Results: On 152 withheld single CT thigh images, the proposed pipeline achieved a mean Dice of 0.888(0.041) across all muscle groups including sartorius, hamstrings, quadriceps femoris and gracilis. muscles Conclusion: To our best knowledge, this is the first pipeline to achieve thigh imaging domain adaptation from MR to CT. The proposed pipeline is effective and robust in extracting muscle groups on 2D single slice CT thigh images.The container is available for public use at https://github.com/MASILab/DA_CT_muscle_seg

Pre-trained protein language models have demonstrated significant applicability in different protein engineering task. A general usage of these pre-trained transformer models latent representation is to use a mean pool across residue positions to reduce the feature dimensions to further downstream tasks such as predicting bio-physics properties or other functional behaviours. In this paper we provide a two-fold contribution to machine learning (ML) driven drug design. Firstly, we demonstrate the power of sparsity by promoting penalization of pre-trained transformer models to secure more robust and accurate melting temperature (Tm) prediction of single-chain variable fragments with a mean absolute error of 0.23C. Secondly, we demonstrate the power of framing our prediction problem in a probabilistic framework. Specifically, we advocate for the need of adopting probabilistic frameworks especially in the context of ML driven drug design.

2D低剂量单板腹部计算机断层扫描（CT）切片可直接测量身体成分，这对于对衰老的健康关系进行定量表征至关重要。然而，由于不同年内获得的纵向切片之间的位置方差，使用2D腹部切片对人体成分变化的纵向分析具有挑战性。为了减少位置差异，我们将条件生成模型扩展到我们的C-斜肌，该模型在腹部区域进行任意轴向切片作为条件，并通过估计潜在空间的结构变化来生成定义的椎骨水平切片。对来自内部数据集的1170名受试者的实验和BTCV Miccai挑战赛的50名受试者的实验表明，我们的模型可以从现实主义和相似性方面产生高质量的图像。来自巴尔的摩纵向研究（BLSA）数据集的20名受试者的外部实验，其中包含纵向单腹部切片验证了我们的方法可以在肌肉和内脏脂肪面积方面与切片的位置方差进行协调。我们的方法提供了一个有希望的方向，将切片从不同的椎骨水平映射到目标切片，以减少单个切片纵向分析的位置差异。源代码可在以下网址获得：https：//github.com/masilab/c-slicegen。

Transformer-based models, capable of learning better global dependencies, have recently demonstrated exceptional representation learning capabilities in computer vision and medical image analysis. Transformer reformats the image into separate patches and realize global communication via the self-attention mechanism. However, positional information between patches is hard to preserve in such 1D sequences, and loss of it can lead to sub-optimal performance when dealing with large amounts of heterogeneous tissues of various sizes in 3D medical image segmentation. Additionally, current methods are not robust and efficient for heavy-duty medical segmentation tasks such as predicting a large number of tissue classes or modeling globally inter-connected tissues structures. Inspired by the nested hierarchical structures in vision transformer, we proposed a novel 3D medical image segmentation method (UNesT), employing a simplified and faster-converging transformer encoder design that achieves local communication among spatially adjacent patch sequences by aggregating them hierarchically. We extensively validate our method on multiple challenging datasets, consisting anatomies of 133 structures in brain, 14 organs in abdomen, 4 hierarchical components in kidney, and inter-connected kidney tumors). We show that UNesT consistently achieves state-of-the-art performance and evaluate its generalizability and data efficiency. Particularly, the model achieves whole brain segmentation task complete ROI with 133 tissue classes in single network, outperforms prior state-of-the-art method SLANT27 ensembled with 27 network tiles, our model performance increases the mean DSC score of the publicly available Colin and CANDI dataset from 0.7264 to 0.7444 and from 0.6968 to 0.7025, respectively.

诸如GPT-3之类的语言模型在研究界引起了愤怒。一些研究发现，GPT-3具有一些创造力，并犯了与人类行为相提并论的错误。本文回答了一个相关的问题：谁是GPT-3？我们为GPT-3管理了两个经过验证的测量工具，以评估其个性，其所持值和自我报告的人口统计。我们的结果表明，GPT -3在人格中与人类样本的分数相似，并且在提供模型响应记忆时 - 根据其所持值。我们提供了对GPT-3模型的心理评估的第一个证据，从而增加了我们对GPT-3模型的理解。我们对未来研究的建议结束，使社会科学更接近语言模型，反之亦然。